Primary Care Network

Mental Health & Hormones

Mental Health & Hormones

Hormonal changes throughout a woman’s life can affect mood, wellbeing, and mental health. Our practice provides assessment, advice, and support for those experiencing symptoms linked to hormonal fluctuations, including PMS, PMDD, perimenopause, and other hormone-related changes.

We follow national guidance from the NHS and work closely with mental health services to ensure safe, effective, and patient-centred care.


PMS / PMDD

Premenstrual Syndrome (PMS) affects up to 8 in 10 women in the days before their period. Premenstrual Dysphoric Disorder (PMDD) is a more severe form, affecting 2–5% of menstruating women.

Symptoms may include:

  • Irritability, mood swings, or anxiety

  • Low mood or tearfulness

  • Fatigue and difficulty sleeping

  • Physical symptoms such as bloating, headaches, or breast tenderness

How we can help:

  • Symptom tracking and assessment

  • Lifestyle advice (exercise, diet, sleep)

  • Pain relief and medications such as hormonal contraception or SSRIs for PMDD

  • Referral to specialist services if needed

Further information:


Mood Changes in Perimenopause

Perimenopause—the transitional period before menopause—can cause fluctuating hormone levels that affect mood and mental wellbeing.

Symptoms may include:

  • Anxiety or irritability

  • Low mood or depressive episodes

  • Poor sleep

  • Fatigue or difficulty concentrating

How we can help:

  • Assessment and monitoring of symptoms

  • Hormone replacement therapy (HRT) where appropriate

  • Non-hormonal interventions including CBT and lifestyle support

  • Referral to specialist menopause or mental health services

Further information:


Anxiety and Depression Linked to Hormonal Shifts

Hormonal changes can trigger or exacerbate mood disorders at various life stages, including:

  • Puberty

  • Pregnancy and postnatal period

  • Perimenopause and menopause

How we can help:

  • Screening and assessment for anxiety or depression

  • Evidence-based treatments including talking therapies and medications

  • Support for sleep, lifestyle, and stress management

  • Referral to specialist mental health services if required

Further information:


When to Seek Help

Contact your GP Practice promptly if you experience:

  • Persistent low mood or anxiety affecting daily life

  • Thoughts of self-harm or suicide

  • Sudden changes in mood that concern you

  • Severe symptoms during PMS/PMDD or perimenopause

We provide confidential, compassionate care and work collaboratively with mental health services to ensure safe and effective support.

Women’s Health Services

If you want to discuss any of these services further, please contact your GP practice to discuss further.